ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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L-Arginine as a potential ergogenic aid in healthy subjects.

However, it cannot be ruled out that creatine in combination with resistance exercise can change transcription or activate satellite cells. This may be related to the lower intensity of such exercise and the associated reduced likelihood of the development of local matching of perfusion to metabolic rate in muscle [ 23 ]. Arginine-based supplements work in some cases, but have several recurring limitations that question the validity of their conclusions.

The possible mechanisms by which VO 2max may be increased following 15 days of nitrate supplementation include NOmediated changes in local perfusion in skeletal muscle and possible effects on cardiac output. Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Arginine is found in a wide variety of protein-rich foods, both plants and animal sources, and normal plasma L-Arginine concentrations depend on age, being homeostasis primarily achieved by catabolic processes [ 35 ].

Effect of supplemental oral l-arginine on exercise capacity in patients with stable angina pectoris. It is unconditionally true that many potentoal feel pressured to use supplements to maintain a competitive advantage over their supplement using-peers, so, physicians should give careful advice in order to prevent serious health risks [ 7 ].


Nitrate supplementation’s improvement of km time-trial performance in trained cyclists.

Meta-analyses have shown an effect of creatine supplementation on body composition and muscular strength in resistance training program 72 Clearly, both exercise in itself and food are much stronger stimuli for protein synthesis than creatine intake in healthy individuals The physiologic context for potential health benefits. A higher VO2max means that more oxygen can be used during exercise.

Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

Oral creatine supplementation and athletic performance: Considering the 27 studies reporting some advantage apparently nitrate-related, 12 of them are based on cycle ergometer protocols, a relevant predominance among other extremely heterogeneous heatlhy such as rowing, apneic series performance, yo-yo tests and maximal treadmill cardiopulmonary exercise testing.

Seven of those 12 studies concluded that Arg supplementation worked as an ergogenic aid. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

New England Journal of Medicine26 Aiv supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states. The rationale for the use of nutritional supplements to enhance exercise capacity is based on the assumption that they will confer an ergogenic effect above and beyond that afforded by regular food ingestion alone. In meta-analyses of the effect of creatine on exercise performance, l-adginine conclusions are also somewhat variable However, during periods of rapid growth, or in response to a traumatic or pathologic insult 5 — 7the demand for arginine may not be fully met by de novo synthesis and normal dietary intake alone.

After oral administration, L-Arginine is extensively metabolized by Arginases in the gut wall and liver, increasing blood flow due to the provision of nitric oxide, providing ad and nutrients [ 223538 ]. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. A reexamination of the effects of creatine on muscle protein synthesis in tissue culture.


We found that 12 of the 20 Arg studies we reviewed included some form of l-arginne supplement Appendix, Table 1. The mechanism underpinning the observed benefits of NO 3 – supplementation on exercise capacity is subiects to be a reduction in the oxygen cost of exercise, as a consequence of a reduced energy cost of contraction or enhanced mitochondrial efficiency.

Like on Arg-based studies, the NO 3 studies produced varying results, though 22 out of 27 showed a performance benefit. The mechanisms underlying the effect of creatine in these circumstances are largely unknown, but may be due to the increased energy in the form of PCr, increased muscle accretion, and stabilization of membranes, as discussed by Persky and Brazeau European Journal of Applied Physiology7 In addition to its acute vasodilatory properties, chronic exposure to nitric oxide also acts to slow a number of the processes associated with the onset of atherosclerosis.

The effect of nitric-oxide-related supplements on human performance. Receive exclusive offers and updates from Oxford Academic. Some studies argue that 15 days of nitrate supplementation may gradually increase VO2 max through NO-mediated changes in skeletal muscle local perfusion, effects on cardiac output, and also increased mitochondrial mass as a consequence of elevated NO availability [ 22 ].

Further, because commercially marketed creatine products do not meet the same quality control standards as pharmaceuticals, there is always a concern of impurities or doses higher or lower than those on the labeling.