Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

Author: Tajar Mezilabar
Country: Croatia
Language: English (Spanish)
Genre: Software
Published (Last): 23 November 2015
Pages: 30
PDF File Size: 10.40 Mb
ePub File Size: 9.28 Mb
ISBN: 306-2-38472-881-6
Downloads: 21986
Price: Free* [*Free Regsitration Required]
Uploader: Mauzshura

Gebhart W, Bardach H. D ICD – Related articles D-penicillamine elastosis perforans serpiginosa lumpy-bumpy elastic fibers. A summary pperforans the 5 cases of elastosis perforance serpiginosa reported in the Korean literature including our case.

This article has been cited by. Cryotherapy was tried a few more times, also without improvement, and the patient was finally re-treated with tazarotene, which flattened her lesions within 6 weeks.

The patient stated that the skin lesions had developed after a skin injury. Find articles by Soo-Chan Kim.

Elastosis Perforans Serpiginosa

Author information Article notes Copyright and Serpiginosz information Disclaimer. Abnormalities of dermal fibrous and elastic tissue Cutaneous condition stubs. Copyright American Medical Association. Purchase access Subscribe to the journal.

While the exact pathogenic process of EPS remains unknown, associations with various underlying systemic conditions and connective tissue disorders have been reported in the literature, including Down’s syndrome, osteogenesis imperfecta, scleroderma, acrogeria, Ehlers-Danlos syndrome type IV vascular typeMarfan syndrome, Rothmund-Thomson syndrome, cutis laxa, diabetes mellitus, perforating folliculitis, and chronic renal failure 89.


The last subtype, idiopathic one, may be associated with genetic basis of the autosomal dominant type of inheritance. At the 1-month follow-up visits, their disease was somewhat improved. Some researchers have demonstrated the effectiveness of the laser light, like Abdullah et al.

Elastosis perforans serpiginosa

Verhoeff-van Gieson staining showed dense clumps of altered elastic fibers in the papillary dermis. The papillary dermis and superficial reticular dermis were infiltrated by numerous inflammatory cells, including lymphocytes and histiocytes Fig. Table 1 A summary of the 5 cases of elastosis perforance serpiginosa reported in the Korean literature including our case. Treatment of elastosis perforans serpiginosa with the pinhole method using a carbon dioxide laser. Purchase access Subscribe now.

Elastosis perforans serpiginosa: a review of the literature and our own experience

Ishak R, Abbas O. However, to date, the candidate gene has not been identified [ 68 ].

The patient was treated unsuccessfully with cryotherapy approximately 6 times; high-potency topical corticosteroids, including clobetasol and halobetasol, for 6 weeks; topical 0. However, no ‘gold standard’ therapy exists among these treatment modalities. A diagnosis of EPS was made based on these clinical and histopathological findings. Seborrheic keratosis Clonal seborrheic keratosis Common seborrheic keratosis Irritated seborrheic keratosis Seborrheic keratosis with squamous atypia Reticulated seborrheic keratosis Dermatosis papulosa nigra Keratosis punctata of the palmar creases other hyperkeratosis: Localized scleroderma Localized morphea Morphea—lichen sclerosus et atrophicus overlap Generalized morphea Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma.


Published by Wolters Kluwer – Medknow. In cases of penicillamine-induced Peeforans, calcification can be observed between the collagen fibers [ 1 — 4 ].

Elastosis perforans serpiginosa – Wikipedia

Sign in to customize your interests Sign in to your personal account. Elastosis perforans serpiginosa is a disorder in which altered elastic fibers are recognized as foreign material and are extruded through the epidermis by transepidermal elimination. Elaetosis cause of abnormal elastic tissue is unknown but may be from a genetic mutation or external factors such as penicillamine.

Each lesion may have a central pit, which is sometimes filled by a crusty or scaly plug.

By using this site, you agree to the Terms of Use and Privacy Policy. Elastosis perforans serpiginosa on the background with acanthosis nigricans.

It looked like entering the canals toward the outside of the skin Fig.